A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs
نویسندگان
چکیده
منابع مشابه
A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs.
In the field of tissue engineering and regenerative medicine there is significant unmet need for critically-sized, fully degradable biomaterial scaffold systems with tunable properties for optimizing tissue formation in vitro and tissue regeneration in vivo. To address this need, we have developed a silk-based scaffold platform that has tunable material properties, including localized and bioac...
متن کاملAdipose Tissue Engineering: Comparing Scaffold-free and Fibrin-based Constructs
Introduction Success of adipose tissue engineering for soft tissue repair has been limited by poor cell survival and insufficient adipogenic differentiation. Although the choice of scaffold can influence these parameters, there is a limited number of studies focussing on the role of scaffolds in cell survival and. adipogenic differentiation. In this study we examined how three-dimensional scaff...
متن کاملfabricating electrospun poly(3-hydroxybutyrate)/hydroxyapatite nanocomposite scaffold for tissue engineering application
. در رســاله ی حاضر، ابتدا داربست نانوالیاف سه بعدی متخلخل به روش الگوبرداری تصویری شبیه سازی شد. با استفاده از طراحی آزمایش به روش تاگوچی پس از ساخت داربست های پلی (3- هیدروکسی بوتیرات) (p3hb) شناسایی رفتار پارامترهای موادی مثل لزجت سیال پلیمر، فراریت و رسانایی الکتریکی محلول پلیمری و پارامترهای دستگاهی مثل دبی حجمی سیال، ولتاژ الکتریکی و فاصله نازل تا جمع کننده صورت گرفت. بعد از محاسبه ی خصوص...
PLGA nanofiber-coated silk microfibrous scaffold for connective tissue engineering.
A modified degumming technique, involving boiling in 0.25% Na2CO3 with addition of 1% sodium dodecyl sulphate and intermittent ultrasonic agitation, was developed for knitted silk scaffolds. Sericin was efficiently removed, while mechanical and structural properties of native silk fibroin were preserved. Biocompatible and mechanically robust hybrid nano-microscaffolds were fabricated by coating...
متن کاملPolymer-Based “Glue Scaffold” with Nanometer-Sized Extracellular Matrix Films for Tissue Engineering
1Department of Chemistry and Biotechnology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan 2Department of Bioengineering, 301 Rhodes Research Center, Clemson University, Clemson, SC 29634-0905, USA 3McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA 4Department of Applied Chemistry, Osaka University 2-1 Yamada-oka Suita, Osak...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomaterials
سال: 2012
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2012.09.017